在上胃肠道瘤学临床试验中的出版偏见临床试验
Trenton Lippert1, Erin Schmucker2, Anchal Shukla3
1University of South Florida Morsani College of Medicine, Tampa, FL, USA. tlippert@usf.edu.
Journal of gastrointestinal cancer
|March 28, 2024
概括
有关胰腺,肝脏和胃癌的重大发现的临床试验更有可能被公布,而不是那些没有重大结果的临床试验. 这种出版偏见影响了基于证据的医学和临床决策.
科学领域:
- 在瘤学瘤学.
- 医学研究方法学 医学研究方法学
- 生物统计学 生物统计学
背景情况:
- 基于证据的医学依赖于全面的医学文献评估.
- 发表偏见,偏爱统计学显著的结果,可能会扭曲文献解释.
- 不完整的数据可能导致不理想的临床推理和患者指导.
研究的目的:
- 为了比较临床试验的发表率和影响,积极的结果与负面的结果.
- 调查上部胃肠道恶性瘤研究中的出版偏见.
主要方法:
- 搜索了美国国家医学图书馆临床试验数据库的胰腺,肝脏和胃癌试验.
- 定义"阳性"试验为具有统计学上显著结果差异的试验,而"负面"试验为非显著的试验.
- 收集了关于试验结束,干预,资金,出版率和期刊指标的数据.
主要成果:
- 有显著发现的试验发表率高 (99%) 比无显著发现的试验 (77%) (p < 0.01).
- 有意义的研究更有可能达到招生目标 (72%) 与无意义的研究相比 (53%) (p < 0.01).
- 发表影响指标显示,在发表后显著和非显著研究之间没有差异.
结论:
- 在上部胃肠道恶性瘤试验中存在有利于显著结果的出版偏差.
- 这种偏见可能导致医学文献不完整,影响基于证据的实践.
- 当前的医学文献可能无法充分捕捉临床决策的关键数据.
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