生物标志物的使用,以量化临床响应全膝关节整形手术干预:一个系统性审查
Mark Mackie1, Kristen I Barton, Darek Sokol-Randell
1From the Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (Mr. Mackie and Dr. Lanting); Orthopaedic Surgery, London Health Sciences Centre, London, ON, Canada (Dr. Barton and Dr. Lanting); School of Physical Therapy, Faculty of Health Sciences, Western University, London, ON, Canada (Dr. Barton); Department of Neurology, Memorial University, Newfoundland, Canada (Dr. Sokol-Randell); Rorabeck Bourne Joint Replacement Clinic, London Health Sciences Centre, Western University, London, ON, Canada (Dr. Lanting).
在全膝关节整形术 (TKA) 后降低术后炎症反应 (PIR) 显著改善了临床结果. 炎症生物标志物和评估有效量化PIR,与疼痛和功能恢复相关.
科学领域:
- 整形外科手术 整形外科手术
- 炎症生物学 炎症生物学
- 生物医学工程 生物医学工程
背景情况:
- 膝关节整形术 (TKA) 可以引起显著的术后炎症反应 (PIR).
- 减弱PIR对患者结果的临床影响仍然是一个关键的研究问题.
- 对于比较研究,需要使用标准化方法来量化PIR.
结论:
- 在TKA后减轻PIR与临床结果的显著改善有关.
- 炎症生物标志物 (CRP,IL-6) 和临床评估对于量化PIR非常有价值.
- 未来的TKA研究应该整合PIR评估,以便对外科技术和手术方案进行可靠的比较.
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