从医疗保健专业人员的角度来看,微成本和摩洛哥皮肤莱什曼病诊断工具的可接受性:一项混合方法研究
Issam Bennis1, Mohamed Sadiki2, Abdelkacem Ezzahidi3
1International School of Public Health, Mohammed VI University of Health and Sciences (UM6SS), Casablanca, Morocco.
PLOS global public health
|March 28, 2024
概括
一个新的快速诊断测试 (RDT) 皮肤莱什曼病 (CL) 对摩洛哥来说是有前途的. 这种CL RDT是可以接受的和具有成本效益的,特别是当在初级医疗保健中心使用一次时.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 皮肤雷什曼病 (CL) 是摩洛哥的一个重大健康问题,由三种寄生虫物种引起.
- 目前的国家控制策略不包括快速诊断测试 (RDTs) 对于CL.
- 评估新型诊断工具对于改善疾病管理至关重要.
研究的目的:
- 在摩洛哥评估CL检测快速测试 (CL-RDT) 的可接受性和微成本.
- 为了比较CL-RDT与传统显微镜的成本效益.
- 为了确定CL-RDT实施的最佳场景.
主要方法:
- 这项研究涉及摩洛哥40个初级卫生保健中心和地区实验室的46名医疗保健专业人员.
- 通过自我管理的问卷和采访收集数据.
- 使用NVivo,Jamovi和Python进行预测建模和灵敏度分析的分析,计算成本效益比 (CBR).
主要成果:
- 由于与显微镜相比,CL-RDT的用户友好性和时间效率得到了很好的接受.
- 显微镜的平均单位成本为15MAD,而CL-RDT的平均单位成本为75MAD.
- 显微镜的总诊断成本略高于CL-RDT (102 MAD) 的总诊断成本 (115 MAD).
- 最具成本效益的场景涉及使用CL-RDT一次在初级医疗保健中心 (CBR = 1.4).
结论:
- 在摩洛哥,CL-RDT是一种可行且具有成本效益的皮肤莱什曼病诊断工具.
- 在初级医疗保健中心实施提供了最佳的成本效益比.
- 该研究主张在资源有限的特有地区部署CL-RDT,预计未来版本的灵敏度将提高.
更多相关视频
11:36Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
Published on: April 21, 2012
22.0K
12:22A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
Published on: December 30, 2012
22.4K
相关概念视频
Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents
Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
