慢性病毒感染会损害对不同病原体的免疫记忆
Cheng Yang1,2, Zhicui Liu2,3, Ying Yang2,4
1Department of Infectious Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
PLoS pathogens
|March 28, 2024
概括
慢性病毒感染会损害已建立的细菌特异性记忆T细胞,减少它们的数量和功能. 这种旁观者效应在持续的病毒感染期间损害了对无关病原体的免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- T细胞生物学T细胞生物学
背景情况:
- 慢性病毒感染会损害T细胞功能,影响病原体清除和免疫记忆.
- 慢性病毒感染对先前存在的对其他病原体的免疫记忆的影响尚不清楚.
研究的目的:
- 研究慢性病毒感染如何影响已建立的细菌特异性记忆T细胞.
- 为了确定慢性淋巴细胞胆膜炎病毒 (LCMV) 感染期间旁观者免疫记忆是否受到损害.
主要方法:
- 小鼠用表达OVA的Listeria monocytogenes (Lm-OVA) 免疫,以产生OVA特异性的记忆T (Tm) 细胞.
- 然后将小鼠感染LCMV菌株Cl-13以确定慢性感染.
- 在Listeria重新挑战后,分析了OVA特异性Tm细胞数量,细胞因子生产和召回反应.
主要成果:
- 长期感染的小鼠显示对Listeria re-challenge的保护受损.
- 在慢性LCMV感染期间,OVA特异性TM细胞数量和效应器功能下降.
- 与病毒特异性耗尽的T细胞不同,OVA特异性Tm细胞没有上调抑制受体,并且未能建立强大的召回反应.
结论:
- 已建立的细菌特异性记忆T细胞在无关的慢性病毒感染期间功能受损.
- 这种损伤可能导致慢性病毒感染的个体对其他病原体的免疫力下降.
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