克罗恩病和性结肠炎内镜评分系统的观察者间和观察者内部变异性:系统性审查和元分析
Jana G Hashash1, Faye Yu Ci Ng2, Francis A Farraye1
1Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, Mayo Clinic, Jacksonville, FL, USA.
Inflammatory bowel diseases
|March 28, 2024
概括
这项研究分析了性结肠炎和克罗恩病的内镜评分系统,发现关键评分工具的观察者间协议中等至良好,观察者内部协议良好至非常好. 改善协议可以提高患者评估和临床试验数据的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 医疗成像医学成像
背景情况:
- 内镜评分对于诊断性结肠炎 (UC) 和克罗恩病 (CD) 是至关重要的.
- 评分的变化会影响患者参加临床试验的资格和治疗疗效的评估.
- 标准化内镜评估对于可靠的患者管理至关重要.
研究的目的:
- 系统地审查和对广泛使用的UC和CD内镜评分系统的观察者间和观察者内部变异性进行元分析.
- 在临床实践中评估特定评分系统的可靠性.
主要方法:
- 观察性研究的系统审查和元分析.
- 包括评估成人患者UC (eMS,UCEIS) 和CD (CDEIS,SES-CD) 的观察者间和观察者内变异性的研究.
- 协议强度的分类:公平,适度,好和非常好.
主要成果:
- 分析了从6003个记录中识别出的13项研究.
- 观察者之间的协议率:eMS (0.58),UCEIS (0.66),CDEIS (0.80),SES-CD (0.78) 这三种方式的数据.
- 观察者内部协议的比率:eMS (0.75),UCEIS (0.87),CDEIS (0.89),SES-CD (0.91) 这几种协议的比率.
- 在各个系统中观察到高异质性 (I2 93.2%99.2%).
结论:
- 对内镜评分系统的观察者间协议范围从中等到良好.
- 内部观察者协议显示出良好的可靠性.
- 加强观察者之间的协议可以导致更精确的患者评估和改善临床试验数据质量.
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