关于早产婴儿多可萨赫萨酸和阿拉基酸补充剂的证据
Alexandre Lapillonne1,2,3, Chiara Lembo1, Sissel J Moltu4
1Department of Neonatology, APHP, Necker-Enfants Malades University Hospital.
Current opinion in clinical nutrition and metabolic care
|March 28, 2024
概括
较高剂量的多可沙赫酸 (DHA) 可能改善早产婴儿的发育. 研究表明,更接近胎儿积累率的DHA补充对婴儿健康结果有希望.
科学领域:
- 新生儿营养新生儿营养
- 发育儿科 发育儿科
- 营养神经科学 营养神经科学
背景情况:
- 在早产婴儿中,传统的多可萨赫萨酸 (DHA) 补充剂,旨在提高母乳水平,产生了不一致的发育和健康结果.
- 之前的研究表明,标准的DHA摄入量可能不足以促进早产婴儿的最佳发育.
研究的目的:
- 为了评估高剂量的DHA补充剂在早产婴儿中的有效性,与胎儿积累率保持一致.
- 探索DHA和阿拉基酸 (ARA) 对早产婴儿结局的联合益处.
- 评估与高度不和脂肪酸补充相关的潜在风险.
主要方法:
- 对早产婴儿DHA补充剂的现有文献和元分析的综述.
- 不同的DHA剂量策略的比较 (母乳水平与胎儿积累率).
- 调查结果包括神经发育,认知功能和早产儿视网膜病变.
主要成果:
- 目前的文献建议使用更高的DHA剂量,更接近胎儿积累率.
- 观察到大脑成熟,长期认知和预防早产视网膜病变的潜在益处.
- 分析没有表明,由于补充不和油,新生儿患病风险显著增加.
结论:
- 优化早产婴儿的DHA摄入量应该与胎儿积累率相一致,而不是平均母乳含量.
- 补充涉及更高DHA水平的补充策略,可能与酸一起,需要进一步调查以改善婴儿结果.
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