精准医学用于个性化治疗过敏呼吸道疾病的药物
1Johns Hopkins University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology, Department of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland, USA.
Current opinion in allergy and clinical immunology
|March 28, 2024
概括
精准医学和个性化医学推进了使用生物标志物和生物制剂的过敏呼吸道疾病治疗. 为了真正个性化治疗,需要进一步整合omics和其他数据.
科学领域:
- 过敏和免疫学的过敏和免疫学.
- 药物基因组学 药物基因组学
- 医疗信息学医学信息学
背景情况:
- 过敏性呼吸道疾病对全球健康构成重大挑战.
- 当前的管理策略从个性化方法中受益.
- 精准医学为量身定制的治疗干预提供了一个框架.
研究的目的:
- 审查精准医学和个性化医学在管理过敏呼吸道疾病中的应用.
- 突出生物标志物和生物疗法的作用.
- 为优化患者护理,确定整合多种数据类型的未来方向.
主要方法:
- 精准医学在过敏呼吸道疾病中的应用文献综述.
- 针对性治疗的生物标志物发现和开发的分析.
- 评估当前和新兴的生物治疗方法.
- 评估数据整合的挑战和机遇.
主要成果:
- 生物标志物识别对于开发针对过敏呼吸道疾病的向生物药物至关重要.
- 一些生物疗法已经成为有效的治疗方法.
- 在应用精准医学原则方面取得了重大进展.
结论:
- 由生物标志物驱动的精准医学正在改变过敏呼吸道疾病的管理.
- 需要进一步的研究来整合omics,临床,行为和社会数据,以获得全面的个性化治疗.
- 优化治疗需要一个整体的,以数据为导向的方法,根据每个人的需求量身定制.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
288
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
288
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma: Pathogenesis and Management
394
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
394
Drugs Used in Lower Respiratory Disorders: Overview
437
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
437
Antiasthma Drugs: Leukotriene Modifiers
291
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
291
Inhaled Medications
256
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
256


