月经前障碍和围产期抑郁症之间的双向关联:来自瑞典的全国性基于登记册的研究
Qian Yang1, Emma Bränn1, Elizabeth R Bertone-Johnson2,3
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
PLoS medicine
|March 28, 2024
概括
月经前障碍 (PMDs) 增加了围产期抑郁症 (PND) 的风险,而PND也增加了患PMDs的风险. 这种双向关联表明,这两种情况都有一个共同的潜在原因.
科学领域:
- 生殖精神病学是一种精神病学.
- 围产期心理健康问题
- 妇女健康研究 妇女健康研究
背景情况:
- 月经前期障碍 (PMDs) 和围产期抑郁症 (PND) 具有共同的症状,并且发生在荷尔蒙波动期间,这表明潜在的共同起源.
- 缺乏关于PMD和PND双向关系的前性数据,这阻碍了有效的临床管理策略.
研究的目的:
- 使用前性收集的数据,调查月经前障碍 (PMD) 和围产期抑郁症 (PND) 之间的双向关联.
- 确定PMD病史是否会增加PND的风险,反之亦然.
主要方法:
- 一项嵌套病例控制研究和一项匹配的队列研究使用瑞典全国性注册 (2001-2018) 进行.
- 通过临床诊断或处方药物确定了PND和PMD的事件病例.
- 统计分析包括条件逻辑回归和分层考克斯回归,并进行兄弟对比以进一步验证.
主要成果:
- PMD与随后的PND风险显著增加有关 (OR 4.76).
- 患有PND的女性患有后续PMD的风险明显更高 (HR 1.81).
- 这种双向关联在产前和产后抑郁症中都被观察到,并且在没有先前精神病史的妇女中更为明显.
结论:
- 在月经前障碍和围产期抑郁症之间存在显著的双向关联.
- 这些发现支持PMD和PND之间共享的病因,表明一个疾病的病史可以告知另一个疾病的风险.
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