SARS-CoV-2 泄漏的持续时间:系统性审查
Anouk M Oordt-Speets1, Julia R Spinardi2, Carlos F Mendoza3
1Epi-C (Epidemiology-Consultancy), the Netherlands.
Journal of global health
|March 28, 2024
概括
在症状出现后5天内,SARS-CoV-2病毒的传播达到顶峰. 在这个峰值之后,传染性病毒培养的阳性性迅速下降,为COVID-19控制策略提供了信息.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 阳性严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 培养物意味着感染性病毒泄露和冠状病毒疾病2019 (COVID-19) 的传播风险.
- 了解SARS-CoV-2的隔离模式对于管理传播至关重要.
研究的目的:
- 为了确定SARS-CoV-2病毒隔离时间的模式.
- 在纵向研究中,量化SARS-CoV-2培养物相对于症状发作或诊断的阳性率.
主要方法:
- 在2023年2月16日之前对PubMed和Embase数据库进行系统审查.
- 在接种疫苗后的时代,包括在SARS-CoV-2感染个体中进行系列病毒培养测试的英语研究.
- 使用纽卡斯尔-太华尺度进行质量评估.
主要成果:
- 包含了14项病毒泄漏研究.
- 阳性SARS-CoV-2培养物在症状出现前4天至症状出现后18天内被发现.
- 从第1天到第5天,文化阳性达到44%-50%的峰值,到第9天下降到11%,到10-17天下降到0%-8%.
结论:
- 在症状发作或诊断后5天内,SARS-CoV-2病毒泄露和培养阳性性峰值.
- 培养积极性的快速下降是在流的高峰期之后.
- 研究结果有助于评估用于控制COVID-19的公共卫生干预措施.
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