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Updated: Jun 29, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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通过一个高效的宏循环药物设计平台,发现了具有强度提高和DMPK特性的宏循环CDK2/4/6抑制剂

Fanye Meng1, Jinxin Liu1, Zhongying Cao1

  • 1Insilico Medicine Shanghai Ltd., Shanghai 201203, China.

Bioorganic chemistry
|March 28, 2024
PubMed
概括

研究人员开发了一个宏循环化平台,以发现新药候选药物. 这个平台有效地创造了一个向循环素依赖激酶 (CDK) 2/4/6的宏循环抑制剂,显示出更好的功效和安全性.

关键词:
在CDK2/4/6/6中使用.循环素依赖的激酶.增强了类似药物的特性.宏观循环化平台是一个巨大的平台.

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