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在酒精依赖中加速表观遗传衰老.

Toshiyuki Shirai1, Satoshi Okazaki1, Ikuo Otsuka1

  • 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.

Journal of psychiatric research
|March 28, 2024
PubMed
概括

酒精依赖加快了表观遗传衰老,特别是在DunedinPACE. 治疗改善了GrimAge和GrimAge2表观遗传钟,同时降低了β-2-微型球蛋白和cystatin C水平.

关键词:
衰老的衰老 衰老的衰老酒精依赖 酒精依赖 酒精依赖通过DNA甲基化.基因表观时钟是什么?

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 衰老研究研究 衰老研究
  • 酒精依赖 酒精依赖 酒精依赖

背景情况:

  • 酒精依赖是一个全球性健康问题,与过早衰老和死亡率有关.
  • 包括GrimAge和DunedinPACE在内的表观遗传钟,为生物衰老提供了新的见解.
  • 没有先前的研究检查了这些特定的表观遗传标记在酒精依赖.

研究的目的:

  • 与对照组相比,研究酒精依赖患者的表观遗传衰老加速.
  • 在酒精依赖中分析基于DNA甲基化的年龄预测成分.
  • 评估治疗对表观遗传衰老标志物的影响.

主要方法:

  • 利用了公开可用的DNA甲基化数据 (GSE98876).
  • 分析了表观遗传时钟:GrimAge,GrimAge2和DunedinPACE. 这三种表观遗传时钟都在使用中.
  • 在患者治疗计划前后比较表观遗传标记.

主要成果:

  • 在酒精依赖患者中,DunedinPACE显示加速衰老.
  • 年龄AccelGrim和年龄AccelGrim2减速后期治疗.
  • 在治疗后,β-2-微型球蛋白和cystatin C水平下降.

结论:

  • 在酒精依赖中,表观遗传衰老发生变化.
  • 治疗可能会逆转表观遗传衰老的一些方面.
  • 研究结果表明,与认知和精神症状有联系.