FOXP3 (不) 稳定性和癌症免疫疗法
1Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Cytokine
|March 28, 2024
概括
调节性T细胞 (Tregs) 的稳定性在疾病中至关重要. 叉头盒P3 (FOXP3) 调节Treg身份和功能,其失调影响癌症免疫治疗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 调节性T细胞 (Tregs) 在免疫平衡中起着至关重要的作用,并与炎症性疾病,自身免疫性疾病和癌症有关.
- 叉头盒P3 (FOXP3) 是一个主转录因子,对Treg谱系的承诺和功能至关重要.
- 对FOXP3的调节失调会影响Treg的稳定性,可能导致免疫抑制功能的丧失,并导致疾病的发病.
研究的目的:
- 审查当前对FOXP3在Treg稳定性和瘤微环境 (TME) 中功能的作用的理解.
- 探索调节FOXP3稳定性的分子机制,包括翻译后的修改 (无化,甲基化,乙化).
- 讨论向FOXP3对癌症免疫治疗策略的影响.
主要方法:
- 本综述综合了关于FOXP3调节及其对癌症Tregs的影响的现有文献.
- 它检查了各种信号通路和调节蛋白 (例如mTORC2,NAC1,Blimp-1,DTX1,USP22) 对FOXP3稳定性的影响.
- 该评论讨论了Treg子集对FOXP3.3的差异依赖.
主要成果:
- FOXP3的稳定性受到信号通路和翻译后修饰的复杂网络的影响.
- 特定的蛋白质和通路可以稳定或破坏FOXP3,影响Treg功能和数量.
- Treg子集对FOXP3的依赖程度各不相同,这表明了不同的调节机制.
结论:
- FOXP3是Treg身份和功能的一个关键决定因素,其稳定性在TME内受到严格监管.
- 准FOXP3或其调节途径是提高癌症免疫治疗疗效的潜在策略.
- 了解不同Treg子集中FOXP3调节的细微差别对于开发有效的治疗干预措施至关重要.
相关概念视频
Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Induced Pluripotent Stem Cells
4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.1K
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K


