BRAFV600E突变不能预测淋巴结转移和复发在中国的乳头甲状腺小癌患者
Hao Zhao1, Chun-Hao Liu2, Ying Lu2
1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100010, China; Surgery Centre of Diabetes Mellitus, Beijing Shijitan Hospital, Capital Medical University, Beijing 100036, China.
Oral oncology
|March 28, 2024
概括
在BRAFV600E突变并不能预测淋巴结转移或复发在中国乳头甲状腺小癌 (PTMC). 然而,大量的淋巴结转移与较差的PTMC预后有关.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 乳头甲状腺癌 (PTC) 的预后与BRAFV600E突变状态有关.
- 在风险分层的乳头甲状腺微癌 (PTMC) 中,BRAFV600E突变的作用仍然存在争议.
研究的目的:
- 研究BRAFV600E突变与中国PTMC患者的临床病理特征之间的关联.
- 评估BRAFV600E突变在中国PTMC中复发的预测值.
主要方法:
- 2094名经过手术和BRAFV600E测试的PTMC患者的回顾性审查.
- 在BRAFV600E-突变和非突变组之间比较临床病理学特征,无病生存期 (DFS) 和治疗反应.
主要成果:
- 在研究队列中,BRAFV600E突变非常普遍 (90.6%).
- 在突变组之间没有观察到淋巴结转移 (LNM) 或3年DFS的显著差异.
- 大量的LNM (超过5) 被确定为PTMC对治疗反应的独立风险因素.
结论:
- BRAFV600E突变不是LNM或中国PTMC中复发的可靠预测因素.
- 大量的LNM显著影响PTMC预后,独立于BRAFV600E状态.
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