经过形内镜性垂体腺瘤切除后妄的相关因素-A匹配的回顾性队列研究
Shusheng Zhang1, Yanan Chen2, Xiudong Wang2
1Traumatic Brain Injury and Neurocritical Center, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, PR China.
概括
下垂体腺瘤手术患者的术后妄想与酒,视神经压缩和更长的手术时间有关. 改善睡眠和减少克制等干预措施可以降低妄想的发生率.
科学领域:
- 神经外科 神经外科
- 麻醉学 麻醉学
- 密集护理医学 密集护理医学
背景情况:
- 妄想是一种常见的术后并发症,特别是在接受复杂神经外科手术的患者中.
- 脑垂体腺瘤的内透膜外科手术带来了独特的挑战,可能会影响术后的认知功能.
- 了解这种患者群体中 Delirium 的特定风险因素对于有针对性的预防策略至关重要.
研究的目的:
- 为了确定发生率和独立的风险因素,与手术后痴呆症的患者进行内透手术进行下垂体腺瘤.
- 提供基于证据的建议,以减少这种手术队列中的妄想发病率.
主要方法:
- 追溯队列研究,包括213名入院到天津黄湖医院头骨底部内镜中心的患者 (2022年1月至12月).
- 用4'A's Test (4AT) 尺度评估 Delirium,最终诊断由临床医生进行.
- 统计分析包括倾向得分匹配 (PSM),奇二次测试和二进制物流回归.
主要成果:
- 手术后狂妄的发生率为29.58% (63/213名患者).
- 确定的独立风险因素包括酒精病史,手术前视神经压缩症状,手术时间≥3小时,使用二来镇静,睡眠障碍和身体克制.
- 倾向分数匹配 (PSM) 用于平衡妄和非妄组之间的共变量 (1:1比).
结论:
- 患有酒精病史,术前视神经压缩和经历较长时间手术 (≥3小时) 的患者患术后狂妄症的风险更高.
- 加强医疗保健提供者与患者之间的沟通,改善外科手术后睡眠质量和减少使用身体限制等策略可能会减轻妄想的发生率.
- 这些发现强调了多因素方法对于在下垂体腺瘤手术患者中预防妄想的重要性.
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