不调节的微RNA和长非编码RNA与细胞外矩阵度相关
Huimin Qiu1, Yi Fu2, Zhinan Guo3
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Yangpu, 200093, Shanghai, China; Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Pudong, 201318, Shanghai, China.
Experimental cell research
|March 28, 2024
概括
细胞外矩阵的刚性通过非编码RNAs (ncRNAs) 影响细胞行为. 本综述探讨了微RNAs (miRNAs) 和长非编码RNAs (lncRNAs) 如何与矩阵度相互作用,影响癌症等疾病.
科学领域:
- 生物医学工程 生物医学工程
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 细胞外矩阵 (ECM) 刚性是细胞功能和组织恒温的关键调节者.
- 来自ECM刚性的机械信号被Piezo1,整蛋白β1和YAP/TAZ等细胞组件感知.
- 非编码RNAs (ncRNAs),包括微RNAs (miRNAs) 和长非编码RNAs (lncRNAs),是细胞过程中的关键参与者.
研究的目的:
- 审查目前对ncRNAs和ECM刚性之间的相互作用的理解.
- 阐明这些相互作用背后的分子机制.
- 突出ECM度调节的ncRNAs在疾病进展和细胞行为中的作用.
主要方法:
- 对研究ncRNAs和ECM度的研究进行文献综述.
- 对参与ECM机械传导的信号通路的分析.
- 整合关于ncRNA参与肝癌,乳腺癌,骨肉瘤和心血管疾病等疾病的发现.
主要成果:
- 特定的miRNAs和lncRNAs是由ECM硬度调节的,影响细胞分化,增殖,迁移,入侵和上皮-介质酶过渡 (EMT).
- 这些ncRNAs与各种癌症和心血管疾病的发病有关.
- 关键的信号通路,包括整合蛋白β1/TGFβ1,PI3K/AKT和EMT通路,与ECM硬度调节的ncRNA相关.
结论:
- ECM度调节的ncRNAs显著影响细胞行为和疾病进展.
- 对这些ncRNA-ECM刚性相互作用的进一步研究可能会揭示新的治疗策略.
- 与ECM相关的ncRNA显示出作为疾病诊断的生物标志物和治疗点的潜力.
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