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对免疫检查点抑制剂的皮肤过敏反应
Ryan Storgard1, Alina Markova1
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
The journal of allergy and clinical immunology. In practice
|March 28, 2024
概括
免疫检查点抑制剂 (ICI) 治疗癌症,但可能导致皮肤问题. 本综述涵盖了影响皮肤的这些常见免疫相关不良事件 (irAEs) 的管理.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 然而,ICI可以引发与免疫相关的不良事件 (irAEs),特别是影响皮肤 (cirAEs).
- cirAEs的范围从常见的皮疹到严重的水泡状况和有毒的表皮解.
研究的目的:
- 对皮肤免疫相关不良事件 (cirAEs) 的当前管理策略和指导方针进行审查.
主要方法:
- 临床研究的文献综述和关于管理cirAEs的指导方针.
- 分析与不同ICI疗法相关的cirAEs发病率.
主要成果:
- 皮肤上注射的IRAE (cirAEs) 是常见的,发生在37-70%的抗CTLA-4治疗患者和17-40%的抗PD-1/PD-L1治疗患者中.
- 脊髓灰质炎的频谱包括各种皮疹,牛皮性皮肤病,牛皮形皮疹和罕见的严重反应.
- 有效的管理策略对于患者护理至关重要.
结论:
- 管理cirAEs需要了解它们的不同临床表现和发病率.
- 本综述综合了当前的方法,以应对这些常见的ICI副作用带来的挑战.
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