柏柏林通过抑制炎症反应和氧化应激抑制SGIV复制,从而抑制SGIV复制
Yunxiang Jiang1, Chengzong Han1, Hannan Gong1
1College of Marine Sciences, South China Agricultural University, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Fish & shellfish immunology
|March 28, 2024
概括
柏柏林 (BBR) 能够有效地抑制新加坡皮病毒 (SGIV) 复制,并通过向关键细胞通路来减少炎症. 这种天然化合物显示出作为水产养殖中SGIV感染的治疗剂的前景.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 新加坡毛虹膜病毒 (SGIV) 在毛水产养殖中造成严重的死亡率和经济损失.
- 柏柏林 (BBR) 是一种植物化物,具有已知的抗病毒,抗氧化和抗炎性质.
研究的目的:
- 通过实验室模型研究Berberine (BBR) 对新加坡皮红斑病毒 (SGIV) 的抗病毒疗效.
- 阐明BBR对SGIV的抗病毒和抗炎作用背后的分子机制.
主要方法:
- 西方污染分析 (Western blot) 是一种分析.
- 在ROS光探针测试中进行测试.
- 实时定量PCR (qRT-PCR) 是一种实时定量PCR.
- NF-κB促进者活动测定
主要成果:
- 在剂量取决的方式,BBR显著抑制了SGIV复制.
- BBR抑制了促炎性细胞因子基因表达和NF-κB通路的激活.
- BBR降低了关键的基因激活蛋白激酶 (ERK,JNK,p38) 的酸化.
- 通过调节抗氧化剂基因表达,BBR减轻了SGIV诱导的氧化应激.
结论:
- 柏柏林在体外对SGIV表现出强大的抗病毒活性.
- BBR通过调节炎症信号通路和氧化应激来发挥其作用.
- BBR代表了在水产养殖中管理SGIV感染的潜在治疗候选者.
更多相关视频
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
47
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
506
相关概念视频
02:26NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
01:28Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K