在默认模式网络和边缘系统中与系统性红斑狼相关的大脑异常:静止状态fMRI元分析
Linhui Wang1, Kai Han2, Qin Huang3
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Journal of affective disorders
|March 28, 2024
概括
系统性红斑狼 (SLE) 患者在关键网络中显示出大脑活动的改变. 本元分析确定了SLE默认模式网络和边缘系统中一致的静止状态功能异常.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种多系统性自身免疫性疾病,具有潜在的神经参与,称为神经精神病性SLE (NPSLE).
- 神经成像研究已经研究了SLE中大脑功能改变,但研究结果往往不一致.
- 这一元分析旨在确定SLE患者的一致的静止状态功能异常.
结论:
- 在SLE中休息状态功能异常主要在默认模式网络和边缘系统中观察到.
- 这些发现揭示了SLE中功能网络变化的一致模式.
- 这些一致的异常可能作为SLE潜在的客观神经成像生物标志物.
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