夜班工作,遗传风险和抑郁风险:一项前性队列研究
Yanchun Chen1, Hongxi Yang2, Yuan Zhang1
1School of Public Health, Tianjin Medical University, Tianjin, China.
Journal of affective disorders
|March 28, 2024
概括
夜班工作增加了抑郁症的风险,无论遗传倾向. 这项研究发现遗传风险和轮班工作之间没有相互作用,这表明夜班对所有人构成风险.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 职业健康 职业健康 职业健康
背景情况:
- 遗传因素和夜班工作都是已知的抑郁症风险因素.
- 遗传倾向和与夜班工作相关的抑郁症风险之间的相互作用需要进一步调查.
研究的目的:
- 为了确定夜班工作是否会增加抑郁风险,而不依赖于个人的遗传倾向.
- 探索与抑郁症有关的遗传风险得分和夜班工作之间的潜在相互作用.
主要方法:
- 利用英国生物库的247,828名成年人的数据,评估了12.7年的中位数随访期间的抑郁风险.
- 使用多基因风险评分 (PRS) 评估遗传倾向,分为低风险,中风险和高风险组.
- 通过问卷量化夜班工作的暴露,将其分为不同的频率和持续时间.
主要成果:
- 夜班工作,包括"轮班工作,但从来没有或很少有夜班"",不规则的夜班"和"永久的夜班",与白天工作相比,与抑郁症的风险明显更高有关.
- 对于每月工作8个晚上以上的个人和那些夜班工作不到10年的个人来说,观察到抑郁症的风险增加.
- 联合分析显示,具有高遗传倾向和夜班工作的人患抑郁症的风险较高,但在遗传倾向和夜班工作之间没有发现显著的相互作用.
结论:
- 夜班工作是抑郁症的一个独立风险因素.
- 夜班工作和抑郁风险之间的关联在不同水平的遗传倾向中是一致的.
- 没有相互作用的证据表明遗传倾向不会改变夜班工作对抑郁风险的影响.
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