老年双相情感障碍的认知:全球档案数据的分析
Federica Klaus1, Hui Xin Ng2, Izabela G Barbosa3
1Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA.
Journal of affective disorders
|March 28, 2024
概括
与健康个体相比,患有双相情感障碍 (BD) 的老年人没有显著的认知差异. 然而,在BD中,更好的认知表现与更少的躁狂症状和更好的功能有关.
科学领域:
- 老年精神病学是一门精神病学专业.
- 神经心理学 神经心理学
- 双极性障碍研究研究
背景情况:
- 认知缺陷显著损害了老年患有双相情感障碍 (OABD) 的成年人的功能.
- 这些缺陷是该人口中残疾的主要原因.
- 了解OABD的认知表现对于有针对性的干预至关重要.
研究的目的:
- 为了比较OABD和年龄相匹配的健康对照 (HC) 之间的认知表现.
- 检查认知表现,症状严重程度和OABD中的功能之间的关联.
- 利用来自国际OABD研究的大型统一数据集.
主要方法:
- 全球衰老和双极性障碍老年实验 (GAGE-BD) 数据库的分析.
- 包括662名50岁以上的参与者 (509名OABD,153名HC)
- 线性混合模型用于评估认知表现 (g-score) 和其相关值.
主要成果:
- 在调整后,OABD和HC组之间的整体认知表现 (g-score) 没有显著差异.
- 显著的相互作用表明,BD的工作人员的认知能力更好.
- 在OABD中,较高的g分数与较少的躁狂症状,高等教育和更好的整体功能相关.
结论:
- 与预期相反,OABD的认知表现可能与HC没有显著差异.
- 在BD中,就业状况似乎是影响认知的重要因素.
- 需要进一步的研究来探索OABD的纵向认知变化和特定领域缺陷,以开发治疗方法.
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