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制备,稳定性和抗菌活性的炭甲基化Anemarrhena asphodeloides多糖化物-花素纳米颗粒加载黄素

Libo Wang¹, Yumeng Zhao¹, YuShun Wang¹

¹College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

International journal of biological macromolecules

|March 28, 2024

概括

新的多糖多电解质纳米颗粒 (CMAAP-CS NPs) 显著提高了黄素 (Cur) 的生物利用性和稳定性. 这些纳米粒子为制药行业的疏水性营养物提供了一个有前途的输送系统.

科学领域:

材料科学材料科学材料科学
生物技术是生物技术.
制药科学制药科学

背景情况:

黄素 (Cur) 由于其疏水性质,具有较差的生物利用性和稳定性.
开发有效的输送系统对于增强像Cur. Cur. 这样的疏水化合物的治疗潜力至关重要.

研究的目的:

为了构建和表征多糖多电解质纳米颗粒 (CMAAP-CS NPs) 使用碳素甲基化Anemarrhena asphodeloides多糖 (CMAAP) 和奇托 (CS).
评估CMAAP-CSNP作为提高黄素 (Cur) 生物可用性和稳定性的载体的疗效.

主要方法:

聚糖多电解质纳米颗粒 (CMAAP-CS NPs) 是通过混合CMAAP和CS合成的.
确定了加载到CMAAP-CS NP中的Cur的粒子大小和捕获效率.
进行了体外模拟消化实验,以评估加载的Cur.的生物可用性.
在CMAAP-CS NP中加载的Cur的稳定性在各种条件下 (储存,加热,紫外线,中性pH) 进行了测试.

主要成果:

在CMAAP-CS中,NP的平均粒子大小为216.60±4.21nm,而Cur.的捕获效率为82.50±2.09%.
在体外消化研究显示,与自由Cur (21.57 ± 0.07%) 相比,加载在CMAAP-CSNP中时,Cur生物可用性显著增加 (59.84 ± 0.03%).
CMAAP-CS NPs证明了Cur对储存,热量,紫外线和中性pH降解的显著保护.

结论:

CMAAP-CS NPs作为一种有效的载体,可以增强黄素的生物可用性和稳定性.
开发的多电解质复合物对制药行业的疏水性营养物质的输送具有前景.

关键词:

生物可用性生物可用性碳素甲基化多糖化物.库尔库明是一种黄素.纳米颗粒纳米颗粒稳定的稳定性稳定的稳定性

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