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Updated: Jun 29, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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利波卡林-2:一种新的潜在治疗GVHD的新疗法

Kate A Markey1

  • 1Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.

Trends in immunology
|March 28, 2024
PubMed
概括

利波卡林-2 (LCN2) 在全源造血干细胞移植 (allo-HCT) 中可以逆转肠道损伤. 研究表明,在小鼠模型中,给予LCN2蛋白质可以预防移植对宿主疾病 (GVHD) 的进展.

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Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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