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癌症的食道切除术后,萨科白会影响术前和生存结果:一项多中心研究
Jin-Soo Park1, Maxwell Colby2, Doruk Seyfi3
1Department of Upper Gastrointestinal and Hepatobiliary Surgery, Royal Prince Alfred Hospital, Sydney, Australia; Royal Prince Alfred Institute of Academic Surgery (RPA IAS), Sydney, Australia; School of Medicine, University of Notre Dame, Sydney, Australia; School of Medicine, University of Sydney, Sydney, Australia; Surgical Outcomes Research Centre (SOuRCe), Sydney, Australia.
通过骨肌指数 (SMI) 识别的手术前的肉,与因食道癌而接受食道切除术的患者的重大并发症增加和较差的生存结果有关.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 外科手术的结果
背景情况:
- 萨尔科佩尼亚对食道切除术结果的影响仍在争论中,非亚洲人群的数据有限.
- 这项研究调查了sarcopenia和术后并发症,存活率和食道切除术后复发之间的关联.
研究的目的:
- 确定手术前的肉和癌症食道切除术后的短期和长期结果之间的相关性.
- 评估食道癌症患者中瘤的独立预后价值.
主要方法:
- 在澳大利亚三所高等医疗中心对462名因癌症而接受食道切除术的患者进行了回顾性分析.
- 使用从手术前CT扫描中获得的骨肌肉指数 (SMI) 定义了sarcopenia.
- 结果包括主要并发症 (Clavien-Dindo ≥3b),整体存活率 (OS) 和无病存活率 (DFS).
主要成果:
- 在59.7%的患者中 (n=276) 存在皮症.
- 麻患者出现较高的严重并发症率 (27.9% vs 14.5%),包括心律失常和肺炎,30天死亡率增加 (5.1% vs 0%).
- 麻症与显著较低的中位数OS (37 vs 114个月) 和DFS (27 vs 77个月) 相关,并且是减少生存的独立预测因素.
结论:
- 通过SMI评估的手术前的肉类是经食道切除术后重大术前并发症的重要危险因素.
- 患有肉症的患者经历了较低的整体存活率和无病存活率,因为食道癌的食道切除术.
- 在这个患者队列中,sarcopenia对瘤学结果和生存率产生了负面影响.
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