牙膏在儿童中对Streptococcus mutans的抗菌作用:一个比较的体外研究
Kubra Tonguc-Altin1, Senem Selvi-Kuvvetli1, Nursen Topcuoglu2
1Department of Pediatric Dentistry, Faculty of Dentistry, Yeditepe University, 34730 Istanbul, Turkey.
The Journal of clinical pediatric dentistry
|March 28, 2024
概括
阿洛韦拉牙膏表现出对Streptococcus mutans的抗菌作用,类似于一些化物牙膏. 这表明非化物成分可以对抗细菌,但对于体内应用需要更多的研究.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙科材料科学 牙科材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化牙膏对像Streptococcus mutans.这样的菌细菌是有效的.
- 对化物的潜在副作用的担忧促使人们开始研究安全的替代成分.
- 研究无化物选择对于开发有效的口腔卫生产品至关重要.
研究的目的:
- 评估含有益生菌,和唾液蛋白质的无化牙膏对Streptococcus mutans的抗菌疗效.
- 为了比较这些无化物选项的抗菌活性与不同度的化牙膏.
- 评估具有抗菌性质的牙膏的生物膜抑制潜力.
主要方法:
- 最低抑制度 (MIC) 和阿加井扩散试验被用于确定对Streptococcus mutans的抗菌活性.
- 生物膜抑制试验是在使用抗菌作用已被证明的牙膏在酸盘上进行的.
- 对照组包括1450 ppm和500 ppm的化牙膏,以及酸缓冲盐水 (PBS) 的负对照.
主要成果:
- 只有 Vera 组 (AV 组) 显示出对 Streptococcus mutans 的抗菌作用,与化控制组相比.
- 与PBS组相比,对照组1和2和AV组观察到Streptococcus mutans生物膜活性的细菌显著减少.
- 在阿洛韦拉组和化对照组之间,在抗菌活性方面没有发现统计学上显著的差异.
结论:
- 商用牙膏可能具有来自非化物成分的抗菌特性.
- 含有的牙膏对Streptococcus mutans具有显著的抗菌活性,尽管效果不如高化物配方.
- 需要进一步的体内和长期研究来证实无化物替代品的临床疗效和安全性.
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