营养不良在全身性硬化症中的频率和影响
Jessica L Fairley1,2, Dylan Hansen2, Alannah Quinlivan1,2
1Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
在全身性硬化症 (SSc) 中,营养不良很普遍,影响了43%的患者. 这种情况显著恶化了SSc.患者的生存率,生活质量和身体功能.
科学领域:
- 类风湿病学 类风湿病学
- 临床营养学 临床营养学
- 结核病研究 结核病研究
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病.
- 营养不良是慢性疾病中公认的并发症.
- 全球营养不良领导倡议 (GLIM) 标准提供了一个标准化的诊断框架.
研究的目的:
- 用GLIM标准确定SSc中营养不良的流行情况.
- 评估营养不良对SSc患者的生存,生活质量和身体功能的影响.
主要方法:
- 来自澳大利亚硬化皮肤症队列研究的数据分析.
- 包括符合ACR/EULAR标准的SSc患者,包括体重和身高测量.
- 应用GLIM标准 (减肥,BMI,肌肉缩) 来诊断营养不良.
- 包括后勤回归和生存模型在内的统计分析 (Kaplan-Meier,Cox比例危险).
主要成果:
- 1903年SSc参与者的43%被诊断为营养不良,33%严重.
- 营养不良的患者年龄较大,更有可能患有扩散皮肤SSc,并且疾病严重程度更高.
- 胃肠道干扰,多病症,肺动脉高血压和上部胃肠道症状与营养不良有关.
- 在营养不良的个体中观察到与健康相关的生活质量和身体功能较差.
- 营养不良独立地与更糟糕的生存率有关 (HR 1.4).
结论:
- 营养不良是系统性硬化症中经常出现的重要问题.
- 根据GLIM标准,可以有效地识别SSc.中的营养不良.
- 营养不良与不良结果有关,包括生存率降低和身体功能和生活质量受损.
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