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对肠道代谢,微生物和大脑功能的综合分析揭示了肠-大脑轴在长寿中的作用

Bin Jiao^1,2,3,4, Ziyu Ouyang¹, Qianqian Liu¹

¹Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

|March 28, 2024

概括

肠道微生物组及其代谢物对非老年人的大脑功能和认知保存有影响. 特定的肠道细菌和神经活性化合物与增强的大脑连接性有关,促进长寿.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
代谢学代谢学代谢学
长寿研究的研究.

背景情况:

微生物群-肠-大脑轴在人类长寿中的作用尚不清楚.
衰老与肠道微生物组和大脑功能的变化有关.

研究的目的:

调查肠道微生物群,代谢物和非老年人的大脑功能之间的关系.
识别与异常长寿和认知保存相关的微生物和代谢特征.

主要方法:

多基因组学分析包括肠道基因组学,代谢学和功能近红外光谱学 (fNIRS).
83名非老年人 (NA) 与81名匹配的非老年人 (NNA) 的比较.
肠道微生物组组成,代谢物概况和大脑连接模式之间的相关性分析.

主要成果:

在NA和NNA之间的438种代谢物中存在显著差异,NA中具有神经活性和抗炎化合物的丰富.
特定的肠道微生物 (Enterocloster asparagiformis,Hungatella hathewayi,Oxalobacter formigenes) 与NAs中的神经活性代谢物相结合.
变化的肠道微生物群和代谢物与NAs中大脑连接的增强有关,特别是涉及前额叶和运动皮质区域.

结论:

神经活性代谢物,特定的肠道微生物和增强的大脑连接性有助于非老年人的认知保存.
这些发现阐明了长寿人口中的微生物群-肠-大脑轴.
对微生物组和代谢物平衡的洞察力,通过改善大脑连接来促进人类的长寿和认知.

关键词:

肠道代谢组是肠道的代谢组.大脑功能大脑功能大脑功能我们的肠道微生物组.肠-大脑轴肠-大脑轴长寿长寿是一个问题.

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