吸烟在创伤中激发了代谢反应
Lauren T Gallagher1, Christopher Erickson, Angelo D'Alessandro
1From the Department of Gastrointestinal, Trauma, and Endocrine Surgery (C.E., A.D., T.S., O.T., W.H., S.M., P.S., C.C.S., M.J.C.), University of Colorado; Ernest E. Moore Shock Trauma Center (E.E.M.), Denver Health; and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Departments of Medicine (C.S.C.) and Anesthesia (C.S.C.), University of Colorado, Aurora, Colorado.
The journal of trauma and acute care surgery
|March 29, 2024
概括
吸烟加剧了创伤患者的氧化应激和线粒体功能障碍,损害了基质利用. 这突出了个性化创伤护理的潜在治疗目标.
科学领域:
- 生物化学 生物化学
- 创伤医学 创伤医学
- 代谢学 代谢学 代谢学
背景情况:
- 吸烟是一个重要的公共卫生问题,与氧化应激和相关疾病有关.
- 吸烟增加了创伤致病率的风险,包括急性呼吸系统应急综合征.
- 吸烟对创伤中的新陈代谢异质性的特定影响仍未得到充分研究.
研究的目的:
- 研究吸烟对受伤患者代谢异质性的机械效应.
- 分析创伤患者的代谢差异,根据吸烟状况分层 (非吸烟者,被动吸烟者,活跃吸烟者).
- 为了比较高损伤/高冲击患者与健康对照者的代谢概况.
主要方法:
- 从一级创伤中心受伤患者的血样本使用基于质谱的代谢学分析.
- 根据科提宁强度对患者进行了分层,分为非吸烟者,被动吸烟者和活跃吸烟者.
- 根据损伤严重性得分 (≥15) 和基数过量 (<-6) 进行分层分类,确定高伤害/高冲击患者.
主要成果:
- 活跃吸烟者 (对照组) 的代谢物升高表明慢性炎症和氧化过程.
- 具有高伤害/高冲击的活跃吸烟者显示,酸盐-酸盐穿,氨酸代谢,肉氨酸合成和非常长链脂肪酸氧化中的丰富.
- 分析包括48名高伤/高震病患者和95名健康对照.
结论:
- 吸烟会放大氧化应激和线粒体功能障碍,加剧创伤中的炎症反应.
- 吸烟与长链脂肪酸,阿斯巴酸和氨酸的利用能力受损有关,增加了受伤后的氧化应激.
- 吸烟者的新陈代谢变化提供了减少创伤患者氧化损伤的潜在治疗点.
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