在对威胁遗漏的反应中,腹中前额叶皮质与随后的明确安全记忆有关
Julian Wiemer1, Franziska Leimeister2, Matthias Gamer2
1Institute of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany. julian.wiemer@uni-wuerzburg.de.
Scientific reports
|March 29, 2024
概括
了解安全记忆是关键. 这项研究表明,腹中前额叶皮质对于记住安全关联至关重要,突出了它在处理缺乏威胁方面的作用.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 记忆研究 记忆研究
背景情况:
- 区分威胁和安全的刺激对于生存至关重要.
- 大脑处理安全感和不存在威胁的机制尚未完全被理解.
- 声明式安全记忆的形成对于适应性行为至关重要.
研究的目的:
- 研究处理安全结果的神经相关性及其对记忆形成的贡献.
- 检查特定大脑区域,包括前额叶和感官皮层在学习和记忆安全方面的作用.
- 将威胁学习与随后的记忆范式结合起来,以评估记忆检索期间的大脑活动.
主要方法:
- 功能磁共振成像 (fMRI) 用于测量38名参与者的大脑活动.
- 使用威胁条件化模式,将有条件刺激 (CS+) 与无条件刺激 (US) 相关联,并呈现无条件刺激 (CS-),没有US的中性刺激.
- 随后的记忆范式评估了大脑对已学会的关联及其结果 (美国和美国的遗漏) 的反应.
主要成果:
- 当威胁关联被记住而不是被遗忘时,海马体活动增加.
- 腹中前额叶皮层预测了后续记忆,特别是安全关联 (CS和US遗漏反应).
- 在一般结果 (美国和美国遗漏) 期间,左背侧前额叶皮质活跃.
- 对美国遗漏的探索性分析揭示了中间前额叶皮层的参与以及与视觉和体感皮层的增强连接.
- 视觉皮层,体感皮层和下额回环中的活动预测了学习后一周的记忆表现.
结论:
- 这些发现强调了处理没有威胁对于建立声明式安全记忆的重要性.
- 前额和感官区域之间的密切相互作用对于处理安全结果和将感官信息与语义记忆集成至关重要.
- 腹中前额叶皮质在安全的声明性记忆中起着特定的作用.
相关概念视频
Role of Amygdala in Memory
213
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
213
Implicit Memories
130
Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...
One key aspect of implicit...
130
Functional Brain Systems: Limbic System
2.7K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
2.7K
Traumatic Memory
89
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
89
Role of Cerebellum and Prefrontal Cortex in Memory
427
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
427
Repressed Memory
86
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
86


