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在轻微的COVID-19感染后,大脑温度和免费水增加
Ayushe A Sharma1,2, Rodolphe Nenert3, Adam M Goodman3
1Department of Neurology, UAB Epilepsy Center, University of Alabama at Birmingham (UAB), 1719 6th Avenue South, CIRC 312, Birmingham, AL, 35294-0021, USA. ayushe.sharma@yale.edu.
Scientific reports
|March 29, 2024
概括
轻微的COVID-19可能会导致长期的大脑变化. 这项研究发现大脑温度升高和免费的水,表明神经炎症,与感染后的认知和嗅觉问题有关.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 传染性疾病 传染性疾病
背景情况:
- 对于COVID-19 (PASC) 后急性后续病理生理学的了解很少,特别是在轻度病例中.
- 慢性神经炎症是持续PASC症状的可疑原因之一.
- 在体内研究神经炎症需要感染前和感染后的数据.
研究的目的:
- 为了研究在轻度COVID-19后的大脑温度和自由水的变化.
- 探索这些变化与神经炎症之间的潜在联系.
- 评估与认知和嗅觉功能障碍的相关性.
主要方法:
- 利用了10名健康个体的独特数据集,在轻度COVID-19之前和之后扫描了10名健康个体.
- 采用了两个新兴的基于磁共振 (MR) 的方法.
- 绘制了COVID-19前后的大脑温度和免费水的变化.
主要成果:
- 在COVID-19后观察到大脑温度和免费水的增加,表明神经炎症.
- 这些变化在与嗅觉,认知和记忆功能相关的大脑区域中被发现.
- 左嗅觉结核显示最大的温度升高 (1.75°C,p=0.007),与嗅觉功能障碍相关.
结论:
- 初步发现表明,在轻度COVID-19后,神经炎症和持续的认知/嗅觉问题之间存在联系.
- 增加的大脑温度和免费的水可以作为神经炎症的间接生物标志物.
- 需要进一步的研究,才能充分理解PASC的潜在机制.
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