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在精神分裂症的皮质视觉空间工作记忆网络中改变了激发性和抑制性离子转移性受体子单元表达

Kirsten E Schoonover^1,2, Samuel J Dienel^1,3,4, H Holly Bazmi¹

¹Translational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|March 29, 2024

概括

精神分裂症改变了视觉处理区域的神经递质受体表达. 在早期视觉区域减少激发性和抑制性受体转录可能会损害高阶大脑区域的信息处理.

科学领域:

神经科学是一个神经科学.
分子精神病学分子精神病学
神经生物学神经生物学神经生物学

背景情况:

精神分裂症 (SZ) 与背部视觉流和视觉空间工作记忆 (vsWM) 网络的功能障碍有关.
在SZ中,刺激性和抑制性神经传递的变化与SZ有关,但受体子单元表达模式在很大程度上是未知的.

研究的目的:

在vsWM网络的关键皮质区域研究离子热性谷氨酸和GABAergic受体子单元的表达模式.
为了确定这些模式是否在精神分裂症患者中发生变化.

主要方法:

量化N-甲基-D-酸盐受体 (NMDAR),α-amino-3-hydroxy-5-methyl-4-isoxazole酸受体 (AMPAR) 和GABA_A受体 (GABAAR) 子单元的mRNA水平.
在未受影响的比较 (UC) 和SZ受试者中,对初级视觉 (V1),视觉关联 (V2),后侧 (PPC) 和背侧前额 (DLPFC) 皮层的死后灰质进行分析.

主要成果:

在UC受试者中,AMPAR和NMDARmRNA显示出对立的面角-尾尾梯度,而GABA_A受体子单元显示出特定区域的峰值.
在SZ受试者中,大多数受体子单元的转录水平明显低于UC受试者,V1的缺陷最大,DLPFC的缺陷最小.

结论:

在健康的vsWM网络中明显的受体表达模式表明特定区域的激发-抑制平衡.
在SZ的早期视觉处理区域中,刺激和抑制受体表达的减少可能是下游信息处理缺陷的基础.

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