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Updated: Jun 29, 2025

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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核进口受体Kapβ2修改了C9orf72-链接ALS/FTD中由多基中介的神经毒性

M E Cicardi1, V Kankate1, S Sriramoji1

  • 1Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.

Communications biology
|March 29, 2024
PubMed
概括

Kapβ2蛋白质保护神经元免受由C9orf72相关的肌缩侧硬化症 (ALS) 和前性痴呆症 (FTD) 中的多糖氨酸-氨酸 (GR) 蛋白质聚合物引起的神经毒性. 抑制Kapβ2可能为这些神经退行性疾病提供治疗策略.

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