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Updated: Jun 29, 2025

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大脑暴露在SARS-CoV-2病毒中会扰乱突触平衡

Emma Partiot^1,2, Aurélie Hirschler^3,4, Sophie Colomb^5,6

¹CNRS, Institut de Recherche en Infectiologie de Montpellier (IRIM), Montpellier, France.

Nature microbiology

|March 29, 2024

概括

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染会影响大脑,导致神经问题. 这项研究揭示了SARS-CoV-2改变了突触组件和电活动,为COVID-19的神经疾病提供了洞察力.

科学领域:

神经科学是一个神经科学.
病毒学病毒学
分子生物学分子生物学

背景情况:

导致COVID-19的严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染与神经系统并发症有关.
由于症状的多样性,这些神经系统后面的分子机制仍然不清楚.

研究的目的:

调查SARS-CoV-2引起的神经并发症的分子机制.
为了阐明SARS-CoV-2和神经细胞之间的相互作用.

主要方法:

利用大脑器官,人类大脑扩展培养物和死后COVID-19大脑样本.
分析了神经细胞对SARS-CoV-2的宽容性.
检查了突触组件和电活动的变化.

主要成果:

感染SARS-CoV-2导致突触元件的表达增加,如Bassoon,拉托菲林-3 (LPHN3) 和富含纤维素蛋白的跨膜蛋白-3 (FLRT3).
该病毒导致异常的前突触形态,并扰乱当地的电场潜力.
用LPHN3激动剂治疗部分恢复了电活动,并扭转了形态变化.
病毒在LPHN3-FLRT3突触中的积累表明在突触干扰中发挥了作用.

结论:

SARS-CoV-2 可以与神经细胞相互作用,导致突触变化和电气干扰.
这些发现为COVID-19相关神经系统疾病的发病过程提供了分子洞察力.
准LPHN3-FLRT3相互作用可能为神经系统并发症提供治疗潜力.

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