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一个常见的调节性哈普洛类型使牛奶中的乳酸铁素度翻了一番
Thomas J Lopdell1, Alexander J Trevarton2, Janelle Moody2
1Research & Development, Livestock Improvement Corporation, Ruakura Road, Hamilton, New Zealand. Thomas.Lopdell@lic.co.nz.
Genetics, selection, evolution : GSE
|March 29, 2024
概括
研究人员确定了一种影响牛奶乳酪蛋白度的遗传类型. 这一发现有助于在专门的奶牛群中选择用于增强乳酸生产的牛.
科学领域:
- 动物基因组学 动物基因组学
- 乳制品科学 乳制品科学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 牛乳酸 (Lf) 是一种具有抗菌性能的结合铁的乳清蛋白.
- 牛奶中的度因环境因素和遗传学而变化.
- 了解Lf的遗传调节对于乳制品生产至关重要.
研究的目的:
- 为了确定调节牛奶中乳酪蛋白度的遗传变异.
- 使用多omics数据集成精确确定致病变体.
主要方法:
- 乳酸铁素蛋白定量特征位点 (pQTL) 的遗传映射.
- 对于表达QTL (eQTL) 的RNA测序 (RNA-seq) 分析.
- 在乳腺组织上进行染色体免疫沉测序 (ChIP-seq) 和转化酶可访问的染色体测序 (ATAC-seq) 的测定.
- 在QTL和变种识别之间进行相关性分析.
主要成果:
- 在乳转素 (LTF) 位点发现了显著的pQTL和cis-eQTL.
- ATAC-seq揭示了在LTF促进体附近的基因影响的染色质可访问性.
- 包括rs110000337在内的115个变异的哈普类型与Lf度的显著变化有关,可能会影响转录因子结合.
结论:
- 监管类型显著影响牛奶中的乳酪蛋白水平.
- 这些遗传洞察力可以指导为奶牛群的高乳酸生产牛的选择.
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