累积的环境压力和在童年时期出现的心脏代谢风险
Alicia S Kunin-Batson1, Jacob Haapala2, A Lauren Crain2
1Department of Pediatrics and Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Pediatric obesity
|March 29, 2024
概括
累积的环境压力增加了儿童心脏代谢风险. 这项研究发现,毛皮质醇不会调解这种联系,这表明需要直接干预,以解决童年不利状况并改善健康结果.
科学领域:
- 环境健康 环境健康
- 儿科卫生健康 儿科卫生健康
- 内分泌学 在内分泌学.
背景情况:
- 儿童心脏代谢风险是一个日益严重的公共卫生问题.
- 累积的环境压力,特别是在低收入家庭,可能会影响儿童的健康.
- 头发皮质醇是下丘脑-垂体-上腺轴活动的生物标志物,反映了慢性压力.
研究的目的:
- 调查累积环境压力与中儿童期心脏代谢风险之间的潜在关联.
- 确定毛皮质醇是否调解环境压力和心脏代谢风险之间的关系.
- 探索不同种族/族群之间环境压力和心脏代谢风险的潜在差异.
主要方法:
- 这是一项对来自低收入家庭的320名儿童进行的纵向队列研究,从2至4岁至7至11岁的儿童进行了跟踪.
- 测量了环境压力因素 (家庭,邻居),头发皮质醇和心脏代谢风险因素 (BMI,血压,脂质,葡萄糖,CRP).
- 使用了调整后勤回归和因果调解分析.
主要成果:
- 较大的累积环境压力显著与心脏代谢风险升高的几率增加有关 (p=0.01).
- 累积压力与较高的皮质醇水平相关 (p<0.01),但皮质醇并没有介导压力-心脏代谢风险联系.
- 来自少数种族/族裔群体的儿童显示,压力因素和心脏代谢风险因素的患病率更高.
结论:
- 累积的环境压力在中年儿童时期显著影响心脏代谢健康.
- 这种压力可能会加剧健康差异,强调需要进行干预.
- 缓解社会经济劣势对于改善儿科心脏代谢健康至关重要.
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