塑化:对中枢神经系统和生殖的结果
Antonietta Santoro1, Marianna Marino1, Laura N Vandenberg2
1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, SA, Italy.
Current neuropharmacology
|March 29, 2024
概括
环境中的微塑料 (MP) 和纳米塑料 (NP) 对大脑和生殖健康构成风险. 需要对可生物降解塑料进行进一步的研究.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
背景情况:
- 无处不在的环境暴露在微塑料 (MPs) 和纳米塑料 (NPs) 中,来自不可生物降解和生物降解的来源是不可避免的.
- 国会议员和NP可以进入食物链并跨越生物障碍,可能影响大脑和生殖腺.
- 广泛的塑料污染,称为塑料化,对人类健康构成潜在的风险.
研究的目的:
- 审查非生物降解和生物降解的MP和NP对大脑和生殖功能的影响.
- 总结分子机制和神经和生殖系统的观察结果.
- 讨论各种模型的数据,包括体外,体外,动物研究和流行病学研究.
主要方法:
- 对现有关于塑料颗粒影响研究的文献综述.
- 分析来自体外和体外实验的数据.
- 来自非哺乳动物和哺乳动物动物模型的研究结果的综合.
- 包括相关的流行病学研究数据.
主要成果:
- 非生物降解的MP和NP显然会影响大脑和生殖器官.
- 关键的不良影响包括氧化应激,慢性炎症,代谢障碍,线粒体功能障碍和细胞毒性.
- 这些影响导致神经炎症,突触功能障碍,代谢失调,雌激素质量受损和生殖毒性.
- 关于可生物降解的MP和NP的具体作用和机制的数据有限.
结论:
- 与MP/NP暴露相关的神经和生殖健康风险需要特别注意.
- 进一步的研究对于了解可生物降解塑料对人类健康的影响至关重要.
- 塑料化可能造成伤害的可能性需要进行持续的调查和风险评估.
更多相关视频
08:11Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
Published on: August 14, 2021
4.5K
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
6.0K
相关概念视频
Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
