探索代谢功能障碍相关的脂肪肝疾病和微量营养素之间的相互作用:从分子机制到临床应用
Yuan Liu1, Xiang Qin1, Tianzhu Chen1
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Frontiers in nutrition
|March 29, 2024
概括
与代谢 (功能障碍) 相关的脂肪肝疾病 (MAFLD) 与不同微量营养素缺乏有关. 针对这些营养不平衡,包括维生素A,D,E和矿物质,可能为MAFLD提供新的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 代谢 (功能障碍) 相关的脂肪肝疾病 (MAFLD) 是一种普遍存在的全球健康问题,其严重程度范围广泛,从简单的脂肪肝到肝细胞癌.
- 目前对MAFLD的治疗选择有限,突出显示迫切需要新的治疗策略.
- 微量营养素水平对生物功能至关重要,并且在MAFLD患者中显示出显著的变化,可能会影响疾病的进展.
研究的目的:
- 审查关键微量营养素 (维生素A,D,E;矿物质:铁,铜,,) 在MAFLD病理生理学的作用.
- 探索微量营养素恒温与MAFLD进展之间的复杂关系.
- 提出基于针对特定维生素和矿物质缺乏症的MAFLD管理的新型治疗策略.
主要方法:
- 关于研究微量营养素水平和MAFLD的综合文献综述.
- 分析微量营养素状况与MAFLD组织病理阶段之间的联系.
- 综合证据以支持针对微量营养素的干预措施.
主要成果:
- 微量营养素缺乏在MAFLD中很常见,并且根据疾病阶段而异.
- 维生素A,D,E,铁,铜,和均质的变化与MAFLD病理生理学有关.
- 有证据表明,微量营养素状况与疾病进展之间存在强烈联系.
结论:
- 微量营养素失衡是MAFLD病原体的组成部分.
- 准特定的维生素和矿物质为MAFLD治疗开发提供了一个有希望的途径.
- 对基于微量营养素的干预措施的进一步研究可以显著改善MAFLD患者的治疗结果.
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