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Updated: Jun 29, 2025

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不同表达的microRNAs在无卵性植入前芽细胞:一个系统的审查

Arwa Almutlaq^1,2, Xavier Viñals Gonzalez¹, Sioban SenGupta¹

¹Reproductive Health, Institute for Women's Health, University College London (UCL), London, United Kingdom.

Frontiers in reproductive health

|March 29, 2024

概括

特定的microRNAs (miRNAs) 在无胚胎胚胎中是下调的,这表明它们作为生物标志物的潜力,用于评估胚胎质量和改善生殖结果.

科学领域:

生殖生物学生殖生物学
遗传学是一个遗传学.
生物标志物发现发现

背景情况:

微RNAs (miRNAs) 是调节基因表达的小型非编码RNAs.
改变的miRNA水平与早期胚胎的无体积相关,表明胚胎质量的潜在生物标志物.
识别与染色体异常相关的特定miRNA对于生殖医学至关重要.

结论:

无胚胎胚胎中特定miRNAs的持续下调支持它们在胚胎发育和遗传异常中的作用.
这些miRNAs显示出作为宝贵的生物标志物对胚胎质量的非侵入性评估具有前途.
使用miRNA分析可能会增强胚胎选择策略,最终改善辅助生殖技术的结果.

关键词:

没有积症.生物标志物生物标志物胚胎细胞囊中的胚胎囊.胚胎质量胚胎质量微RNA (miRNA) 是一种微型RNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...