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甲基酸酶缺乏的THP-1细胞显示出一种疾病特征的炎症前型表型

Frouwkje A Politiek1,2, Marjolein Turkenburg1, Rob Ofman1

  • 1Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, Netherlands.

Frontiers in immunology
|March 29, 2024
PubMed
概括

梅瓦诺酸激酶缺乏症 (MKD) 由于异oprenoid合成受损而引起炎症. 缺乏MK的细胞模仿MKD,揭示了与代谢转变和改变的激酶活性相关的促炎状态,有助于疾病研究.

关键词:
自炎症性疾病 自炎症性疾病细胞因子 细胞因子超高IgD综合征是什么天生的免疫反应.异类生物合成异类生物合成梅瓦诺酸激酶缺乏症是什么?

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