作为对光疗的反应,瘤微环境的免疫调节
Trisha I Valerio1, Coline L Furrer1, Negar Sadeghipour1,2
1Stephenson School of Biomedical Engineering University of Oklahoma, Norman, Oklahoma 73019, USA.
Journal of innovative optical health sciences
|March 29, 2024
概括
将光疗与免疫疗法结合起来,可以通过克服免疫抑制性瘤微环境来增强抗瘤免疫力. 这种方法通过激活免疫细胞并促进全身抗瘤反应,提高了癌症治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物医学工程 生物医学工程
背景情况:
- 瘤微环境 (TME) 抑制了免疫系统,限制了癌症治疗的有效性.
- 目前的治疗方法很难克服这种免疫抑制的TME.
- 免疫疗法和光疗法显示出有希望的结果,但它们本身也有局限性.
研究的目的:
- 审查结合光疗与其他癌症治疗的协同效应.
- 讨论光疗增强免疫疗法的成功和局限性.
- 探索这种组合如何重塑免疫抑制性TME.
主要方法:
- 对光疗与各种癌症治疗方式相结合的文献综述.
- 对瘤消除和TME调节的协同效应的分析.
- 评估免疫细胞激活和全身抗瘤反应.
主要成果:
- 光疗诱导免疫细胞死亡,增强抗瘤免疫力.
- 组合疗法可以改善瘤杀伤效应和免疫细胞透.
- 光疗-免疫疗法将TME重新连接到一个促炎状态.
结论:
- 光疗结合其他疗法,特别是免疫疗法,可以克服TME抑制.
- 这种组合策略激活了针对局部和远程瘤的先天性和适应性免疫力.
- 它在免疫细胞中建立了亲炎性表型,促进了全身抗瘤反应.
相关概念视频
01:27Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K