可卡因自我管理行为与可卡因使用障碍患者的皮质下和皮质形态测量有关
Robert J Kohler1, Simon Zhornitsky1,2, Marc N Potenza1,2,3,4,5,6
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
The American journal of drug and alcohol abuse
|March 29, 2024
概括
纹状体和岛状体的大脑结构差异与可卡因使用障碍 (CUD) 有关. 这些区域的灰质体积和厚度可能会影响CUD患者的可卡因消费和自我管理行为.
科学领域:
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
- 神经成像是一种神经成像.
背景情况:
- 大脑灰质的个体差异,特别是在边缘系统和前皮层,与可卡因使用障碍 (CUD) 有关.
- 与自我报告方法相比,自我管理模式提供了更直接的可卡因使用监管措施.
研究的目的:
- 为了研究可卡因自我管理行为与大脑皮层下和皮层区域的灰色物质形态学之间的关系.
- 为了确定条形体,杏仁体和海马体中的灰质量 (GMV) 与自我注射可卡因输液的数量是否相关.
- 为了检查额叶皮层厚度是否与自我管理的可卡因量有关.
主要方法:
- 从33名中度至重度CUD患者中收集了结构MRI数据和可卡因自给药数据.
- 参与者经历了60分钟的自我管理会话,在FR1计划中使用不同剂量的可卡因 (8,16或32毫克/70公斤),并进行5分钟的锁定.
- 对皮层下和皮层区域进行回归分析,对年龄,实验变量和使用史进行控制.
主要成果:
- 可卡因注入与尾部灰色物质体积 (GMV) 有积极的关联,与门GMV有负面的关联.
- 在皮层区域,可卡因注入与岛屿厚度有积极的关联.
- 女性似乎比男性更频繁地自我服用可卡因.
结论:
- 条状体和岛状体的灰质形态学可能在CUD个体中可卡因消费中发挥作用.
- 观察到的大脑形态学差异可能是长期使用可卡因,易受伤害或其他因素的结果.
- 这些发现突出了理解和治疗CUD的潜在神经生物学目标.
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