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Updated: Jun 29, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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PD-1 限制IL-2 生产和胸膜调节T细胞发育

Breanna Caruso1, Benjamin R Weeder2, Reid F Thompson2,3,4,5

  • 1Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR.

ImmunoHorizons
|March 29, 2024
PubMed
概括

编程细胞死亡蛋白1 (PD-1) 通过调节T细胞受体信号传递和IL-2产生来调节胸腺中的调节性T细胞 (Treg) 发育. 这一发现为癌症和感染的免疫检查点阻塞疗法提供了洞察力.

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

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In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function09:26

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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