F-FDG专用乳腺PET补充乳腺MRI,用于评估对新辅助化疗的早期反应
Devan Diwanji1, Natsuko Onishi1, Deep K Hathi1
1From the Departments of Radiology and Biomedical Imaging (D.D., N.O., D.K.H., C.L.H., W.L., R.G., Y.S., R.R.F., B.N.J., N.M.H., E.F.J., K.M.R.), Epidemiology and Biostatistics (J.K.), and Surgery (J.M.V., L.J.E.), University of California San Francisco, 550 16th St, San Francisco, CA 94158; and I-SPY 2 Advocacy Group, San Francisco, Calif (D.H., S.B.).
Radiology. Imaging cancer
|March 29, 2024
概括
18 (18F) 氧葡萄糖 (FDG) 专用乳腺PET (dbPET) 在新辅助化疗 (NAC) 期间显示出早期治疗反应. dbPET为动态对比增强MRI提供了补充信息,用于评估乳腺癌治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 核医学就是核医学.
背景情况:
- 新辅助化疗 (NAC) 是侵袭性乳腺癌的标准治疗方法.
- 准确的治疗反应早期评估对于优化患者的治疗结果至关重要.
- 定量成像生物标志物有可能预测治疗反应.
研究的目的:
- 在NAC早期使用F-FDG dbPET和DCE-MRI比较瘤代谢和 perfusion 的定量测量.
- 评估这些成像模式对早期治疗变化的敏感性.
- 确定这些方法是否为治疗反应评估提供了补充信息.
主要方法:
- 在20名参与者中,对DCE-MRI和F-FDG dbPET进行前性分析,这些参与者在基线 (T0) 和3周后 (T1) 的NAC中患有22种侵入性乳腺癌.
- 对dbPET参数 (SUV,MTV,TLG) 和MRI参数 (PE,SER,FTV) 的计算.
- 根据受体状态,Ki-67指数和残留癌症负担分层的成像参数的比较,使用Wilcoxon签名排名和Mann-Whitney U测试.
主要成果:
- 高基-67的瘤显示出更高的基线SUV和SUV.
- 在T1.1观察到F-FDG dbPET (SUVmax,SUVmean,SUVpeak,TLG) 和DCE-MRI (SERpeak,FTV) 测量均显著下降.
- 响应性瘤与不响应性瘤相比,SUVmax和PEpeak的相对变化更大.
结论:
- 在乳腺癌中,F-FDG dbPET对NAC期间的早期代谢变化敏感.
- dbPET为DCE-MRI提供了补充信息,用于评估治疗反应.
- 这些定量成像技术可能有助于评估NAC的有效性.
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