生命早期的过敏敏感和呼吸道感染是否相互作用增加喘风险?
Vikas Wadhwa1, Danielle Wurzel2, Shyamali C Dharmage1
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
概括
该研究没有发现证据表明早期过敏敏感和呼吸道感染相互作用增加喘风险. 这两个因素独立地增加了喘风险,需要密切监测受影响的儿童.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- "双击"假设表明,早期的过敏敏感化和呼吸道感染相互作用,从而增加喘风险.
- 了解这种相互作用对于开发有效的喘预防策略至关重要.
研究的目的:
- 在高风险出生队伍中研究早期过敏敏感化和呼吸道感染之间的相互作用.
- 为了确定这种相互作用是否与6-7岁和18岁的喘风险增加有关.
主要方法:
- 一项出生队列研究通过皮肤刺痛测试评估了在6,12和24个月的过敏敏感性.
- 呼吸道感染被监测了15个月,18个月和2年.
- 回归分析检查了6-7岁和18岁的喘结果,并调整了混因素.
主要成果:
- 过敏敏感性与6至7岁的喘几率更高显著相关 (OR = 14.46).
- 对喘风险的过敏敏感化和呼吸道感染之间没有发现显著的相互作用.
- 在6-7岁的敏感和非敏感儿童中,高达2岁的呼吸道感染增加与更高的喘几率有关.
结论:
- 这些发现不支持关于喘风险的"双击"假设.
- 早期的呼吸道感染和过敏敏感性都是儿童喘的独立风险因素.
- 患有这两种疾病的儿童需要密切监测喘的发展.
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