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Updated: Jun 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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亚克拉斯皮罗基类A-B,纳基类衍生的多基类,具有前所未有的 [6 + 6 + 6 + 6] + [5 + 5] 螺旋结构

Fleurdeliz Maglangit1, Shan Wang2, Arvin Moser3

  • 1Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu, Gorordo Ave., Lahug, Cebu City, 6000 Philippines.

Journal of natural products
|March 29, 2024
PubMed
概括

两种新型的多基基虫,A和B基虫,从一个突变的Streptomyces中分离出来. 这些化合物对抗格拉姆阳性细菌表现出强烈的活性,包括一种耐药的Enterococcus faecium菌株.

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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
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Prochirality

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