非典型的阿尔茨海默病:对语言和视觉变体之间重叠的频谱的新见解
Neha Atulkumar Singh1, Jonathan Graff-Radford1, Mary M Machulda2
1Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Journal of neurology
|March 29, 2024
概括
非典型的阿尔茨海默病 (AD) 经常显示语言和视觉症状之间的重叠. 大多数患者都表现出这两种情况,这对诊断具有挑战性,并强调需要对阿尔茨海默病变体进行全面评估.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 非典型的阿尔茨海默氏病 (AD) 变体存在,主要是语言或视觉空间缺陷.
- 这些变体及其神经解剖学基础之间的重叠程度尚未得到充分理解.
研究的目的:
- 研究非典型阿尔茨海默病中重叠的语言和视觉症状的频率和神经解剖学相关性.
主要方法:
- 评估了82名生物标志物确认的AD患者,主要是语言或视觉缺陷.
- 方法包括临床评估,MRI用于结构变化,和[18F]flortaucipir-PET用于tau病理.
- 小组分析的重点是语言/视觉测试以及脑缩和陶积累的模式.
主要成果:
- 观察到明显的重叠:28%的语言组有视觉功能障碍,47%的视觉组有语言障碍.
- 神经成像显示了渐进的腰叶和额叶参与.
- 视力缺陷的恶化与语言群体中较大的腰头/额头参与相关.
- 在视觉组中,语言缺陷的恶化与左侧门/额头参与相关.
结论:
- 纯语言或视觉呈现很少 (25%) 在非典型的AD.
- 综合征重叠在非典型的AD中很常见,这给诊断带来了挑战.
- 综合性评估对于准确的非典型阿尔茨海默病变体表型是至关重要的.
关键词:
非典型的阿尔茨海默氏症疾病语言开放的渐进性失语症.这就是为什么MRI是MRI.后皮层缩 后皮层缩淘宝PET 宝贝宝贝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝宝更多相关视频
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