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Updated: Jun 29, 2025

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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科林林通过调节NF-κB/MAPK和Nrf2信号通路来抑制骨质细胞形成和减弱ROS活动

Chen Jin1,2, Xian-Bin Yu1,2, Jiayi Yang3

  • 1Department of Orthopaedic, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Journal of agricultural and food chemistry
|March 29, 2024
PubMed
概括

从传统的中国草药中提取的科林林 (Cor) 有效地抑制骨质细胞形成和骨再吸收. 这种化合物通过调节关键信号通路和恢复骨质在临床前模型中显示出治疗骨质疏松症的潜力.

关键词:
通过NF-κB/MAPKs的途径.在 Nrf2 路径上.科里诺林 (Corynoline) 是一种可的化合物.骨质结晶体的骨质细胞.有活性氧物种的反应性氧物种.

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