法语非洲的伤寒肠道穿孔,一个范围审查
Leah Sukri1, Audry Banza2, Katherine Shafer2
1Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
PLOS global public health
|March 29, 2024
概括
伤寒肠道穿孔 (TIP) 在法语非洲显著影响儿童和年轻人,导致高发病率和死亡率. 改善的卫生条件和台风联合疫苗对于预防至关重要.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 伤寒肠道穿孔 (TIP) 是非洲腹膜炎和紧急手术的主要原因,特别影响高死亡率的儿科人口.
- 西方数据库中关于TIP的现有数据倾向于英语国家,限制了对法语非洲情况的理解.
- 由于传染病的高发病率,有必要评估法语非洲国家的TIP负担.
研究的目的:
- 在法语非洲国家确定伤寒肠道穿孔 (TIP) 的发病率和发病率.
- 整合和分析来自这个代表性不足的地区的TIP现有数据.
- 在受研究的人群中确定与TIP相关的主要人口和临床特征.
主要方法:
- 使用PubMed,EMBASE和SCOPUS数据库进行了范围审查,搜索与法语非洲国家的腹膜炎,阴茎穿孔和伤寒相关的术语.
- 通过与非洲外科医生的直接接触和引用追逐来获取西方数据库中无法获得的数据,搜索得到了增强.
- 分析包括来自12个国家的32项研究,包括22个法语出版物.
主要成果:
- 伤寒肠道穿孔 (TIP) 占急性周周炎病例中位数的35%,患者中位数年龄为20岁.
- 报告的TIP死亡率在6%至37%之间 (中位数为16%),并发症率在15%至92%之间 (中位数为46%),差异很大.
- 对于TIP治疗而言,乳腺瘤创建率在各医院之间有很大的差异,从0%到79%,尼日尔的发病率最高.
结论:
- 伤寒肠道穿孔 (TIP) 在法语非洲是一个重大挑战,其特点是患病率和死亡率高,主要影响儿童和年轻人.
- 干预措施,如改善卫生条件和将伤寒联合疫苗纳入常规免疫计划,有望减少伤寒发病率和并发症.
- 从法语非洲国家进一步的研究和数据收集对于全面了解和有效管理TIP至关重要.
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