创伤性脑损伤和创伤后应激障碍及其对阿尔茨海默病病理学的发展和发展模式的影响
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Journal of Alzheimer's disease : JAD
|March 29, 2024
概括
创伤性脑损伤 (TBI) 和创伤后应激障碍 (PTSD) 并没有显著增加阿尔茨海默病 (AD) 的风险,也没有改变AD的典型病理模式,尽管有些人发展AD病理.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 老年学是指老年学的学科.
背景情况:
- 创伤性脑损伤 (TBI) 和创伤后应激障碍 (PTSD) 被调查为痴呆的潜在风险因素,包括阿尔茨海默病 (AD).
- 关于TBI,PTSD和AD风险的现有研究提出了不一致的发现.
- 这项研究通过探索具有不同AD病理脆弱性的潜在子组来解决这些不一致问题.
研究的目的:
- 为了确定是否存在不同阿尔茨海默病 (AD) 病理脆弱性的子组,在有或没有创伤性脑损伤 (TBI) 或创伤后应激障碍 (PTSD) 史的个人中存在.
- 调查这些潜在的子组是否具有不典型的tau负载和灰质缩模式.
主要方法:
- 利用了国防部ADNI数据库中89名受试者的MRI和PET数据.
- 计算了一种年龄校正的灰质tau不匹配度量 (ageN-T不匹配分数和矩阵),以评估tau驱动的缩.
- 采用分层集群分析来识别灰质相互作用的空间模式.
主要成果:
- 年龄N-T不匹配得分与β-粉样蛋白负载和认知功能相关,但不是TBI或PTSD严重程度.
- 层次集群分析揭示了五种不同的灰质相互作用模式,反映了典型的AD tau进展.
- 没有一个特定的集群与创伤后应激障碍或创伤后创伤病史完全相关.
结论:
- 单独或结合TBI或创伤后应激障碍的病史与生命后期发展AD病理的风险没有显著增加.
- 远程TBI或PTSD似乎没有改变AD病理学的特征分布模式.
- 虽然一些TBI/PTSD患者可能会发展AD病理,但这些情况不会改变AD的基本进展或风险概况.
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