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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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Propagation of Homalodisca coagulata virus-01 via Homalodisca vitripennis Cell Culture
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环境特异性病毒细胞代谢重编程

Cristina Howard-Varona1, Morgan M Lindback2, Jane D Fudyma3,4

  • 1Department of Microbiology, The Ohio State University, 484 W 12th Ave, Columbus, OH 43210, United States.

The ISME journal
|March 29, 2024
PubMed
概括
此摘要是机器生成的。

病毒在营养稀缺的情况下改变了微生物的新陈代谢. 这项研究揭示了病毒感染的细胞 (病毒细胞) 在酸盐限制期间如何采用不同的生存和复制策略.

关键词:
细菌 细菌 细菌是一种细菌.生态学生态学是什么海洋海洋的海洋海洋的海洋代谢重编程是指代谢重编程.多种主题的多种主题.限制营养素的限制病毒细胞病毒细胞.病毒 病毒 病毒 病毒

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科学领域:

  • 微生物生态学 微生物生态学
  • 病毒学 病毒学
  • 系统生物学 系统生物学

背景情况:

  • 病毒通过影响宿主细胞,基因转移和营养循环,显著影响微生物生态系统.
  • 被病毒感染的细胞,称为病毒细胞,随着病毒劫持细胞机械,表现出改变的新陈代谢.
  • 在营养有限的条件下,维罗细胞的代谢适应仍然在很大程度上未被探索.

研究的目的:

  • 通过系统生物学方法研究在营养限制下病毒细胞的代谢重编程.
  • 了解低酸盐条件如何影响不同菌体感染的海洋细菌病毒细胞.
  • 为了识别在营养压力期间病毒细胞使用的常见和特定的代谢策略.

主要方法:

  • 利用系统生物学方法结合了转录组学,蛋白组学,脂组学和代谢组学.
  • 评估了低酸盐条件对海性Pseudoalteromonas宿主病毒细胞的影响,这些病毒细胞被HP1和HS2菌体感染.
  • 分析了内和外代谢物,以获取全面的代谢概况.

主要成果:

  • 低酸盐诱导了常见的细胞反应,包括酸盐应激反应激活和减少有机物质消耗.
  • 对低酸盐的感染特异性反应包括增强的同化和改变的脂质代谢.
  • 病毒细胞表现出不同的策略:HS2病毒细胞增加了转录和核糖体生产,而HP1病毒细胞积累了宿主蛋白和扩大了资源获取.

结论:

  • 环境条件对所有细胞施加一般的代谢反应,无论病毒感染如何.
  • 病毒细胞开发特定的代谢策略,以支持在营养限制下病毒复制.
  • 建立了一个框架,用于研究自然环境中营养有限的病毒细胞的代谢策略.