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系统性硬化症相关的肺动脉高血压的特征是独特的外围T辅助细胞形状

Theodoros Ioannis Papadimitriou^1,2, Jacqueline M J Lemmers¹, Arjan P M van Caam¹

¹Department of Rheumatology, Radboudumc, Nijmegen, The Netherlands.

Rheumatology (Oxford, England)

|March 29, 2024

概括

系统性硬化症患者患有严重的血管并发症,如肺动脉高血压,表现出不同的T细胞形状. 这表明自身免疫性炎症在SSc血管问题中的作用.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
血管生物学血管生物学

背景情况:

系统性硬化症 (SSc) 呈现出各种临床问题,特别是血管病变.
免疫系统与SSc相关的血管问题之间的联系尚不清楚.
肺动脉高血压 (PAH) 是SSc血管病变的严重表现.

研究的目的:

为了研究SSc患者的免疫参数.
在SSc.中识别与血管严重性相关的外围T细胞子集.
探索免疫系统在SSc相关的血管并发症中的作用.

主要方法:

收集了来自30名SSc患者,5名异形性PAH患者和15名健康捐赠者的周围血液和临床数据.
根据年龄,性别和药物,匹配了PAH和没有PAH的SSc患者.
使用多色流细胞计量的量化淋巴细胞子集.

主要成果:

与HD患者相比,SSc患者的外围T辅助细胞 (Tph) 增加,CD4+GZMB+T细胞增加,Th1细胞减少.
在SSc中发现CD4+和CD8+耗尽型T细胞的增加,细胞因子/细胞毒性信号增加.
患有PAH的SSc患者表现出明显的T辅助体形状,Th17和Tph细胞增加.

结论:

患有严重血管病变 (PAH) 的SSc患者表现出独特的T细胞特征.
这种独特的T细胞形状暗示了自身免疫性炎症在SSc血管并发症中的潜在作用.

关键词:

的T淋巴细胞.生物标志物生物标志物肺动脉高血压肺动脉高血压系统性硬化症系统性硬化症血管病变是一种血管病变.

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